Burgos, N;
Cardoso, MJ;
Thielemans, K;
Modat, M;
Pedemonte, S;
Dickson, J;
Barnes, A;
... Ourselin, S; + view all
(2014)
Attenuation correction synthesis for hybrid PET-MR scanners: application to brain studies.
IEEE Trans Med Imaging
, 33
(12)
2332 - 2341.
10.1109/TMI.2014.2340135.
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Abstract
Attenuation correction is an essential requirement for quantification of positron emission tomography (PET) data. In PET/CT acquisition systems, attenuation maps are derived from computed tomography (CT) images. However, in hybrid PET/MR scanners, magnetic resonance imaging (MRI) images do not directly provide a patient-specific attenuation map. The aim of the proposed work is to improve attenuation correction for PET/MR scanners by generating synthetic CTs and attenuation maps. The synthetic images are generated through a multi-atlas information propagation scheme, locally matching the MRI-derived patient's morphology to a database of MRI/CT pairs, using a local image similarity measure. Results show significant improvements in CT synthesis and PET reconstruction accuracy when compared to a segmentation method using an ultrashort-echo-time MRI sequence and to a simplified atlas-based method.
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