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Update on the management of cholangiocarcinoma

Skipworth, JR; Keane, MG; Pereira, SP; (2014) Update on the management of cholangiocarcinoma. Digestive Diseases , 32 (5) 570 - 578. 10.1159/000360507. Green open access

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Abstract

Cholangiocarcinoma (CC) is a rare cancer arising from the epithelium of the biliary tree, anywhere from the small peripheral hepatic ducts to the distal common bile duct. Classification systems for CC typically group tumours by anatomical location into intrahepatic, hilar or extrahepatic subtypes. Surgical resection or liver transplantation remains the only curative therapy for CC, but up to 80% of patients present with advanced, irresectable disease. Unresectable CC remains resistant to many chemotherapeutic agents, although gemcitabine, particularly in combination with other agents, has been shown to improve overall survival. Ongoing investigation of biological agents has also yielded some promising results. Several novel interventional and endoscopic techniques for the diagnosis and management of non-operable CC have been developed: initial results show improvements in symptoms and progression-free survival, but further randomised studies are required to establish their role in the management of CC.

Type: Article
Title: Update on the management of cholangiocarcinoma
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1159/000360507
Publisher version: http://dx.doi.org/10.1159/000360507
Language: English
Additional information: Copyright © 2014 S. Karger AG, Basel.
Keywords: Bile Duct Neoplasms, Bile Ducts, Intrahepatic, Cholangiocarcinoma, Humans, Neoplasm Metastasis, Neoplasm Staging
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/1436160
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