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A method for reconstructing tomographic images of evoked neural activity with electrical impedance tomography using intracranial planar arrays

Aristovich, KY; dos Santos, GS; Packham, BC; Holder, DS; (2014) A method for reconstructing tomographic images of evoked neural activity with electrical impedance tomography using intracranial planar arrays. Physiol Meas , 35 (6) 1095 - 1109. 10.1088/0967-3334/35/6/1095. Green open access

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Abstract

A method is presented for reconstructing images of fast neural evoked activity in rat cerebral cortex recorded with electrical impedance tomography (EIT) and a 6 × 5 mm(2) epicortical planar 30 electrode array. A finite element model of the rat brain and inverse solution with Tikhonov regularization were optimized in order to improve spatial resolution and accuracy. The optimized FEM mesh had 7 M tetrahedral elements, with finer resolution (0.05 mm) near the electrodes. A novel noise-based image processing technique based on t-test significance improved depth localization accuracy from 0.5 to 0.1 mm. With the improvements, a simulated perturbation 0.5 mm in diameter could be localized in a region 4 × 5 mm(2) under the centre of the array to a depth of 1.4 mm, thus covering all six layers of the cerebral cortex with an accuracy of <0.1 mm. Simulated deep brain hippocampal or thalamic activity could be localized with an accuracy of 0.5 mm with a 256 electrode array covering the brain. Parallel studies have achieved a temporal resolution of 2 ms for imaging fast neural activity by EIT during evoked activity; this encourages the view that fast neural EIT can now resolve the propagation of depolarization-related fast impedance changes in cerebral cortex and deeper in the brain with a resolution equal or greater to the dimension of a cortical column.

Type: Article
Title: A method for reconstructing tomographic images of evoked neural activity with electrical impedance tomography using intracranial planar arrays
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/0967-3334/35/6/1095
Publisher version: http://dx.doi.org/10.1088/0967-3334/35/6/1095
Language: English
Additional information: © 2014 Institute of Physics and Engineering in Medicine. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Keywords: Animals, Brain Mapping, Computer Simulation, Electric Impedance, Electrodes, Hippocampus, Image Processing, Computer-Assisted, Rats, Tomography
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1436091
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