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Albumin infusion improves renal blood flow autoregulation in patients with acute decompensation of cirrhosis and acute kidney injury

Garcia-Martinez, R; Noiret, L; Sen, S; Mookerjee, R; Jalan, R; (2015) Albumin infusion improves renal blood flow autoregulation in patients with acute decompensation of cirrhosis and acute kidney injury. Liver International , 35 (2) 335 - 343. 10.1111/liv.12528. Green open access

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Abstract

In cirrhotic patients with renal failure, renal blood flow autoregulation curve is shifted to the right, which is consequent upon sympathetic nervous system activation and endothelial dysfunction. Albumin infusion improves renal function in cirrhosis by mechanisms that are incompletely understood. We aimed to determine the effect of albumin infusion on systemic haemodynamics, renal blood flow, renal function and endothelial function in patients with acute decompensation of cirrhosis and acute kidney injury.

Type: Article
Title: Albumin infusion improves renal blood flow autoregulation in patients with acute decompensation of cirrhosis and acute kidney injury
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/liv.12528
Publisher version: http://dx.doi.org/10.1111/liv.12528
Language: English
Additional information: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Keywords: acute kidney injury, albumin, cirrhosis, endothelial dysfunction, human, refractory ascites, renal blood flow
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/1434851
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