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Interactions between HIV-1 and the cell-autonomous innate immune system.

Towers, GJ; Noursadeghi, M; (2014) Interactions between HIV-1 and the cell-autonomous innate immune system. Cell Host Microbe , 16 (1) 10 - 18. 10.1016/j.chom.2014.06.009. Green open access

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Abstract

HIV-1 was recognized as the cause of AIDS in humans in 1984. Despite 30 years of intensive research, we are still unraveling the molecular details of the host-pathogen interactions that enable this virus to escape immune clearance and cause immunodeficiency. Here we explore a series of recent studies that consider how HIV-1 interacts with the cell-autonomous innate immune system as it navigates its way in and out of host cells. We discuss how these studies improve our knowledge of HIV-1 and host biology as well as increase our understanding of transmission, persistence, and immunodeficiency and the potential for therapeutic or prophylactic interventions.

Type: Article
Title: Interactions between HIV-1 and the cell-autonomous innate immune system.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.chom.2014.06.009
Publisher version: http://dx.doi.org/10.1016/j.chom.2014.06.009
Language: English
Additional information: © 2014 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/1434612
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