Towers, GJ;
Noursadeghi, M;
(2014)
Interactions between HIV-1 and the cell-autonomous innate immune system.
Cell Host Microbe
, 16
(1)
10 - 18.
10.1016/j.chom.2014.06.009.
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Abstract
HIV-1 was recognized as the cause of AIDS in humans in 1984. Despite 30 years of intensive research, we are still unraveling the molecular details of the host-pathogen interactions that enable this virus to escape immune clearance and cause immunodeficiency. Here we explore a series of recent studies that consider how HIV-1 interacts with the cell-autonomous innate immune system as it navigates its way in and out of host cells. We discuss how these studies improve our knowledge of HIV-1 and host biology as well as increase our understanding of transmission, persistence, and immunodeficiency and the potential for therapeutic or prophylactic interventions.
| Type: | Article |
|---|---|
| Title: | Interactions between HIV-1 and the cell-autonomous innate immune system. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.chom.2014.06.009 |
| Publisher version: | http://dx.doi.org/10.1016/j.chom.2014.06.009 |
| Language: | English |
| Additional information: | © 2014 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1434612 |
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