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Low-dose phase contrast tomography with conventional x-ray sources

Hagen, CK; Munro, PRT; Endrizzi, M; Diemoz, PC; Olivo, A; (2014) Low-dose phase contrast tomography with conventional x-ray sources. [Letter]. Medical Physics , 41 (7) , Article 070701. 10.1118/1.4884297. Green open access

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Abstract

Purpose: The edge illumination (EI) x-ray phase contrast imaging (XPCi) method has been recently further developed to perform tomographic and, thus, volumetric imaging. In this paper, the first tomographic EI XPCi images acquired with a conventional x-ray source at dose levels below that used for preclinical small animal imaging are presented. Methods: Two test objects, a biological sample and a custom-built phantom, were imaged with a laboratory-based EI XPCi setup in tomography mode. Tomographic maps that show the phase shift and attenuating properties of the object were reconstructed, and analyzed in terms of signal-to-noise ratio and quantitative accuracy. Dose measurements using thermoluminescence devices were performed. Results: The obtained images demonstrate that phase based imaging methods can provide superior results compared to attenuation based modalities for weakly attenuating samples also in 3D. Moreover, and, most importantly, they demonstrate the feasibility of low-dose imaging. In addition, the experimental results can be considered quantitative within the constraints imposed by polychromaticity. Conclusions: The results, together with the method's dose efficiency and compatibility with conventional x-ray sources, indicate that tomographic EI XPCi can become an important tool for the routine imaging of biomedical samples.

Type: Article
Title: Low-dose phase contrast tomography with conventional x-ray sources
Location: USA
Open access status: An open access version is available from UCL Discovery
DOI: 10.1118/1.4884297
Publisher version: http://dx.doi.org/10.1118/1.4884297
Language: English
Additional information: © 2014 American Association of Physicists in Medicine.. All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.
Keywords: Medical x-ray imaging, computed tomography, x-ray imaging, illumination, image reconstruction
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1434334
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