UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Elucidating Poor Decision-Making in a Rat Gambling Task

Rivalan, M; Valton, V; Seriès, P; Marchand, AR; Dellu-Hagedorn, F; (2013) Elucidating Poor Decision-Making in a Rat Gambling Task. PLoS ONE , 8 (12) , Article e82052. 10.1371/journal.pone.0082052. Green open access

[img] PDF
journal.pone.0082052.pdf
Available under License : See the attached licence file.

Download (1MB)

Abstract

Although poor decision-making is a hallmark of psychiatric conditions such as attention deficit/hyperactivity disorder, pathological gambling or substance abuse, a fraction of healthy individuals exhibit similar poor decision-making performances in everyday life and specific laboratory tasks such as the Iowa Gambling Task. These particular individuals may provide information on risk factors or common endophenotypes of these mental disorders. In a rodent version of the Iowa gambling task – the Rat Gambling Task (RGT), we identified a population of poor decision makers, and assessed how these rats scored for several behavioral traits relevant to executive disorders: risk taking, reward seeking, behavioral inflexibility, and several aspects of impulsivity. First, we found that poor decision-making could not be well predicted by single behavioral and cognitive characteristics when considered separately. By contrast, a combination of independent traits in the same individual, namely risk taking, reward seeking, behavioral inflexibility, as well as motor impulsivity, was highly predictive of poor decision-making. Second, using a reinforcement-learning model of the RGT, we confirmed that only the combination of extreme scores on these traits could induce maladaptive decision-making. Third, the model suggested that a combination of these behavioral traits results in an inaccurate representation of rewards and penalties and inefficient learning of the environment. Poor decision-making appears as a consequence of the over-valuation of high-reward-high-risk options in the task. Such a specific psychological profile could greatly impair clinically healthy individuals in decision-making tasks and may predispose to mental disorders with similar symptoms.

Type: Article
Title: Elucidating Poor Decision-Making in a Rat Gambling Task
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0082052
Publisher version: http://dx.doi.org/10.1371/journal.pone.0082052
Language: English
Additional information: © 2013 Rivalan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
UCL > Provost and Vice Provost Offices > VP Innovation and Enterprise
UCL > Provost and Vice Provost Offices > VP Innovation and Enterprise > UCL Advances - Ctr for Entrepreneurship
URI: https://discovery.ucl.ac.uk/id/eprint/1434148
Downloads since deposit
128Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item