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Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: A case study.

Singh, H; Cooper, RJ; Wai Lee, C; Dempsey, L; Edwards, A; Brigadoi, S; Airantzis, D; ... Austin, T; + view all (2014) Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: A case study. Neuroimage Clin , 5 256 - 265. 10.1016/j.nicl.2014.06.012. Green open access

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Abstract

Seizures in the newborn brain represent a major challenge to neonatal medicine. Neonatal seizures are poorly classified, under-diagnosed, difficult to treat and are associated with poor neurodevelopmental outcome. Video-EEG is the current gold-standard approach for seizure detection and monitoring. Interpreting neonatal EEG requires expertise and the impact of seizures on the developing brain remains poorly understood. In this case study we present the first ever images of the haemodynamic impact of seizures on the human infant brain, obtained using simultaneous diffuse optical tomography (DOT) and video-EEG with whole-scalp coverage. Seven discrete periods of ictal electrographic activity were observed during a 60 minute recording of an infant with hypoxic-ischaemic encephalopathy. The resulting DOT images show a remarkably consistent, high-amplitude, biphasic pattern of changes in cortical blood volume and oxygenation in response to each electrographic event. While there is spatial variation across the cortex, the dominant haemodynamic response to seizure activity consists of an initial increase in cortical blood volume prior to a large and extended decrease typically lasting several minutes. This case study demonstrates the wealth of physiologically and clinically relevant information that DOT-EEG techniques can yield. The consistency and scale of the haemodynamic responses observed here also suggest that DOT-EEG has the potential to provide improved detection of neonatal seizures.

Type: Article
Title: Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: A case study.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.nicl.2014.06.012
Publisher version: http://dx.doi.org/10.1016/j.nicl.2014.06.012
Language: English
Additional information: PMCID: PMC4141980 © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Keywords: Diffuse optical tomography (DOT), Functional near infrared spectroscopy (fNIRS), Hypoxic–ischaemic encephalopathy (HIE), Neonatal seizures
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1434039
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