Schaller, T;
Bauby, H;
Hué, S;
Malim, MH;
Goujon, C;
(2014)
New insights into an X-traordinary viral protein.
Front Microbiol
, 5
, Article 126. 10.3389/fmicb.2014.00126.
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Abstract
Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.
| Type: | Article |
|---|---|
| Title: | New insights into an X-traordinary viral protein. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fmicb.2014.00126 |
| Publisher version: | http://dx.doi.org/10.3389/fmicb.2014.00126 |
| Additional information: | © 2014 Schaller, Bauby, Hué, Malim and Goujon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | HIV-1, HIV-2, SAMHD1, SIVsmm, interferon type I, myeloid cells, restriction factor, vpx |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1433816 |
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