Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients

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Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients

Walsh, J; Cram, A; Woertz, K; Breitkreutz, J; Winzenburg, G; Turner, R; Tuleu, C; (2014) Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients. Advanced Drug Delivery Reviews , 73 14 - 33. 10.1016/j.addr.2014.02.012. Green open access

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Abstract

The development of paediatric medicines can be challenging since this is a diverse patient population with specific needs. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Acceptable palatability of oral paediatric medicinal products is of great importance to facilitate patient adherence. This has been recognised by regulatory authorities and so is becoming a key aspect of paediatric pharmaceutical development studies. Many active pharmaceutical ingredients (APIs) have aversive taste characteristics and so it is necessary to utilise taste masking techniques to improve the palatability of paediatric oral formulations. The aim of this review is to provide an overview of different approaches to taste masking APIs in paediatric oral dosage forms, with a focus on the tolerability of excipients used. In addition, where possible, the provision of examples of some marketed products is made.

Type:	Article
Title:	Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients
Location:	Netherlands
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1016/j.addr.2014.02.012
Publisher version:	http://dx.doi.org/10.1016/j.addr.2014.02.012
Language:	English
Additional information:	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords:	Dosage form, Excipient, Formulation, Paediatric, Palatability, Taste masking
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI:	https://discovery.ucl.ac.uk/id/eprint/1433799