Greene, ND;
Copp, AJ;
(2014)
Neural tube defects.
Annual Review of Neuroscience
, 37
pp. 221-242.
10.1146/annurev-neuro-062012-170354.
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Abstract
Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth defects of the central nervous system that originate during embryonic development when the neural tube fails to close completely. Human NTDs are multifactorial, with contributions from both genetic and environmental factors. The genetic basis is not yet well understood, but several nongenetic risk factors have been identified as have possibilities for prevention by maternal folic acid supplementation. Mechanisms underlying neural tube closure and NTDs may be informed by experimental models, which have revealed numerous genes whose abnormal function causes NTDs and have provided details of critical cellular and morphological events whose regulation is essential for closure. Such models also provide an opportunity to investigate potential risk factors and to develop novel preventive therapies.
| Type: | Article |
|---|---|
| Title: | Neural tube defects |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1146/annurev-neuro-062012-170354 |
| Publisher version: | http://dx.doi.org/10.1146/annurev-neuro-062012-170... |
| Language: | English |
| Additional information: | Posted with permission from the Annual Review of Neuroscience, Volume 37 © 2014 by Annual Reviews, http://www.annualreviews.org. All rights reserved. |
| Keywords: | anencephaly, spina bifida, folic acid, genetics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1433573 |
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