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A semi-automated technique for labeling and counting of apoptosing retinal cells

Bizrah, M; Dakin, SC; Guo, L; Rahman, F; Parnell, M; Normando, E; Nizari, S; ... Cordeiro, MF; + view all (2014) A semi-automated technique for labeling and counting of apoptosing retinal cells. BMC Bioinformatics , 15 (1) 169 -180. 10.1186/1471-2105-15-169. Green open access

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Abstract

Retinal ganglion cell (RGC) loss is one of the earliest and most important cellular changes in glaucoma. The DARC (Detection of Apoptosing Retinal Cells) technology enables in vivo real-time non-invasive imaging of single apoptosing retinal cells in animal models of glaucoma and Alzheimer's disease. To date, apoptosing RGCs imaged using DARC have been counted manually. This is time-consuming, labour-intensive, vulnerable to bias, and has considerable inter- and intra-operator variability

Type: Article
Title: A semi-automated technique for labeling and counting of apoptosing retinal cells
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2105-15-169
Publisher version: http://dx.doi.org/10.1186/1471-2105-15-169
Additional information: © 2014 Bizrah et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1432362
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