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A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe

Mocroft, A; Reiss, P; Rakhmanova, A; Banhegyi, D; Phillips, AN; De Wit, S; Ristola, M; ... for EuroSIDA in EuroCOORD, ; + view all (2014) A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe. Infection , 42 (4) pp. 757-762. 10.1007/s15010-014-0630-4. Green open access

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Abstract

ATRIPLA is licensed for use only in HIV-positive persons whose viral loads <50 for ≥3 months. We investigated the use of ATRIPLA as first-line antiretroviral therapy (ART) in EuroSIDA using a web-based survey performed in Autumn 2012. 96/112 clinics (85.7 %) completed the survey. Recommendations when initiating first-line ART was TRUVADA plus efavirenz in 36 (37.5 %), ATRIPLA in 35 (36.5 %), a different first-line regimen in 12 clinics (12.5 %), and no recommendation in 7 clinics (7.3 %). ATRIPLA was commonest in Northern (15/21 clinics; 71.4 %), and least common in Eastern Europe (2/31 clinics; 6.5 %; p < 0.0001). Over one-third of the participating clinics in this survey were using ATRIPLA as first-line antiretroviral therapy, despite EMA recommendations.

Type: Article
Title: A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s15010-014-0630-4
Publisher version: http://dx.doi.org/10.1007/s15010-014-0630-4
Additional information: ©� The Author(s) 2014. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1431979
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