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Modifiable cardiovascular disease risk factors as predictors of dementia death: pooling of ten general population-based cohort studies

Batty, GD; Russ, TC; Starr, JM; Stamatakis, E; Kivimäki, M; (2014) Modifiable cardiovascular disease risk factors as predictors of dementia death: pooling of ten general population-based cohort studies. Journal of Negative Results in BioMedicine , 13 , Article 8. 10.1186/1477-5751-13-8. Green open access

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Abstract

Background: With drug treatment for dementia being of limited effectiveness, the role of primary prevention, in particular the predictive value of modifiable cardiovascular disease risk factors, may warrant exploration. The evidence base is, however, characterised by discordant findings and is modest in size. Accordingly, we examined the association of modifiable cardiovascular disease risk factors with dementia death. / Design and methods: We pooled raw data from 10 UK general population-based prospective cohort studies within the context of an individual participant meta-analysis. / Results: A total of 103,764 men and women were followed up for a mean of 8 years giving rise to 443 dementia-related deaths and 2612 cardiovascular disease deaths. Cardiovascular disease mortality was, as anticipated, associated with the full range of risk factors under study, including raised blood pressure, smoking, diabetes, physical inactivity. By contrast, dementia death was related to very few of the cardiovascular disease risk factors: of those classified as modifiable, only smoking was associated with a raised risk and higher levels of non-HDL with a lower risk. / Conclusions: In the present individual participant meta-analysis, there was limited evidence that cardiovascular disease risk factors were related to dementia death.

Type: Article
Title: Modifiable cardiovascular disease risk factors as predictors of dementia death: pooling of ten general population-based cohort studies
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1477-5751-13-8
Publisher version: http://dx.doi.org/10.1186/1477-5751-13-8
Language: English
Additional information: Copyright © 2014 Batty et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/1431736
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