Marculescu, C;
Kossen, H;
Morgan, RE;
Mayer, P;
Fletcher, SA;
Tolner, B;
Chester, KA;
... Baker, JR; + view all
(2014)
Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds.
Chemical Communications
, 50
(54)
pp. 7139-7142.
10.1039/c4cc02107j.
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Abstract
Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new methods for protein modification at disulfide bonds.
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