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Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds

Marculescu, C; Kossen, H; Morgan, RE; Mayer, P; Fletcher, SA; Tolner, B; Chester, KA; ... Baker, JR; + view all (2014) Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds. Chemical Communications , 50 (54) pp. 7139-7142. 10.1039/c4cc02107j. Green open access

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Abstract

Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new methods for protein modification at disulfide bonds.

Type: Article
Title: Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c4cc02107j
Publisher version: http://dx.doi.org/10.1039/c4cc02107j
Additional information: This journal is ©The Royal Society of Chemistry 2014. This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence
Keywords: Cysteine, Disulfides, GRB2 Adaptor Protein, Maleimides, Somatostatin
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1431164
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