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Value of antibodies to free light chains in immunoperoxidase studies of renal biopsies.

Owen-Casey, MP; Sim, R; Cook, HT; Roufosse, CA; Gillmore, JD; Gilbertson, JA; Hutchison, CA; (2014) Value of antibodies to free light chains in immunoperoxidase studies of renal biopsies. J Clin Pathol , 67 (8) pp. 661-666. 10.1136/jclinpath-2014-202231. Green open access

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Abstract

Because immunoglobulin abnormalities may affect the kidney, investigation of renal biopsies requires immunohistological study of light chains. A problem is that most antibodies to light chains react with whole immunoglobulins as well as free light chains, and there are generally many more whole immunoglobulins than free light chains. The usefulness of antibodies that only detected free light chains was investigated.

Type: Article
Title: Value of antibodies to free light chains in immunoperoxidase studies of renal biopsies.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jclinpath-2014-202231
Publisher version: http://dx.doi.org/10.1136/jclinpath-2014-202231
Additional information: © 2014 by the BMJ Publishing Group Ltd & Association of Clinical Pathologists. All rights reserved. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/3.0/
Keywords: light chains, sensitivity and specificity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1430528
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