Owen-Casey, MP;
Sim, R;
Cook, HT;
Roufosse, CA;
Gillmore, JD;
Gilbertson, JA;
Hutchison, CA;
(2014)
Value of antibodies to free light chains in immunoperoxidase studies of renal biopsies.
J Clin Pathol
, 67
(8)
pp. 661-666.
10.1136/jclinpath-2014-202231.
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Abstract
Because immunoglobulin abnormalities may affect the kidney, investigation of renal biopsies requires immunohistological study of light chains. A problem is that most antibodies to light chains react with whole immunoglobulins as well as free light chains, and there are generally many more whole immunoglobulins than free light chains. The usefulness of antibodies that only detected free light chains was investigated.
| Type: | Article |
|---|---|
| Title: | Value of antibodies to free light chains in immunoperoxidase studies of renal biopsies. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/jclinpath-2014-202231 |
| Publisher version: | http://dx.doi.org/10.1136/jclinpath-2014-202231 |
| Additional information: | © 2014 by the BMJ Publishing Group Ltd & Association of Clinical Pathologists. All rights reserved. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/3.0/ |
| Keywords: | light chains, sensitivity and specificity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1430528 |
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