Smart, AL;
Gaisford, S;
Basit, AW;
(2014)
Oral peptide and protein delivery: intestinal obstacles and commercial prospects.
Expert Opinion on Drug Delivery
, 11
(8)
pp. 1323-1335.
10.1517/17425247.2014.917077.
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Abstract
Pharmaceutical research and development is increasingly focussed on biopharmaceuticals including peptide and protein drugs. Despite their growing importance and almost 100 years of research, the vast majority are still only available by injection. Oral bioavailabilities of peptide and protein drugs are very low mainly because of the stability and permeability barriers of the gastrointestinal (GI) tract.
| Type: | Article |
|---|---|
| Title: | Oral peptide and protein delivery: intestinal obstacles and commercial prospects. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1517/17425247.2014.917077 |
| Publisher version: | http://dx.doi.org/10.1517/17425247.2014.917077 |
| Language: | English |
| Additional information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Opinion on Drug Delivery in August 2014, available online: http://dx.doi.org/10.1517/17425247.2014.917077. |
| Keywords: | biopharmaceuticals, colonic drug targeting, gastrointestinal metabolism, insulin, macromolecules, oral delivery strategies, oral peptide/protein bioavailability, Administration, Oral, Biological Availability, Chemistry, Pharmaceutical, Drug Delivery Systems, Humans, Intestinal Absorption, Peptides, Proteins |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1430080 |
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