Asquith, CR;
Meli, ML;
Konstantinova, LS;
Laitinen, T;
Peräkylä, M;
Poso, A;
Rakitin, OA;
... Hilton, ST; + view all
(2014)
Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection.
Bioorganic and Medicinal Chemistry Letters
, 24
(12)
2640 - 2644.
10.1016/j.bmcl.2014.04.073.
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Abstract
A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.
Type: | Article |
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Title: | Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.bmcl.2014.04.073 |
Publisher version: | http://dx.doi.org/10.1016/j.bmcl.2014.04.073 |
Language: | English |
Additional information: | © 2014. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. |
Keywords: | FIV, HIV-1, NCp7, Nucleocapsid protein, Scorpionine |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
URI: | https://discovery.ucl.ac.uk/id/eprint/1430061 |
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