UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection

Asquith, CR; Meli, ML; Konstantinova, LS; Laitinen, T; Peräkylä, M; Poso, A; Rakitin, OA; ... Hilton, ST; + view all (2014) Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection. Bioorganic and Medicinal Chemistry Letters , 24 (12) 2640 - 2644. 10.1016/j.bmcl.2014.04.073. Green open access

[thumbnail of Hilton_BioorgMedChemLett-Hilton.pdf]
Preview
Text
Hilton_BioorgMedChemLett-Hilton.pdf

Download (603kB) | Preview

Abstract

A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.

Type: Article
Title: Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bmcl.2014.04.073
Publisher version: http://dx.doi.org/10.1016/j.bmcl.2014.04.073
Language: English
Additional information: © 2014. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0.
Keywords: FIV, HIV-1, NCp7, Nucleocapsid protein, Scorpionine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1430061
Downloads since deposit
168Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item