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Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data.

Fiorentino, A; O'Brien, NL; Locke, DP; McQuillin, A; Jarram, A; Anjorin, A; Kandaswamy, R; ... Gurling, HM; + view all (2014) Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data. Bipolar Disord , 16 (6) pp. 583-591. 10.1111/bdi.12203. Green open access

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Abstract

Genetic markers in the genes encoding ankyrin 3 (ANK3) and the α-calcium channel subunit (CACNA1C) are associated with bipolar disorder (BP). The associated variants in the CACNA1C gene are mainly within intron 3 of the gene. ANK3 BP-associated variants are in two distinct clusters at the ends of the gene, indicating disease allele heterogeneity.

Type: Article
Title: Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bdi.12203
Publisher version: http://dx.doi.org/10.1111/bdi.12203
Additional information: © 2014 The Authors. Bipolar Disorders Published by John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: DNA sequencing, L-type calcium channel, allelic association study, ankyrin 3, bipolar disorder, genetic
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > EDI Continuing Professional Develop.
URI: https://discovery.ucl.ac.uk/id/eprint/1429246
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