UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Co-Trimoxazole Prophylaxis Is Associated with Reduced Risk of Incident Tuberculosis in Participants in the Swiss HIV Cohort Study

Hasse, B; Walker, AS; Fehr, J; Furrer, H; Hoffmann, M; Battegay, M; Calmy, A; ... Study, SHIVC; + view all (2014) Co-Trimoxazole Prophylaxis Is Associated with Reduced Risk of Incident Tuberculosis in Participants in the Swiss HIV Cohort Study. Antimicrobial Agents and Chemotherapy , 58 (4) 2363 - 2368. 10.1128/AAC.01868-13. Green open access

[thumbnail of 3_Manuscript_AAC_COT_incidentTbc_revision_2014_01_27.pdf]
Preview
PDF
3_Manuscript_AAC_COT_incidentTbc_revision_2014_01_27.pdf

Download (354kB)

Abstract

Cotrimoxazole reduces mortality in HIV-infected adults with tuberculosis (TB), and in vitro data suggest potential anti-mycobacterial activity of cotrimoxazole. We aimed to evaluate whether prophylaxis with cotrimoxazole is associated with a decreased risk of incident TB in SHCS participants. We determined the incidence of TB per 1000 person-years from January 1992 to December 2012. Rates were analyzed separately in participants with current or no previous antiretroviral treatment (ART) using Poisson regression adjusted for CD4 cell count, sex, region of origin, injecting drug use, and age. 13,431 cohort participants contributed 107,549 person-years follow-up; 182 patients had incident TB; 132 (73%) before and 50 (27%) after ART initiation. The multivariable incidence rate ratios for cumulative cotrimoxazole exposure per year for persons with no previous and current ART were 0.70 (95% CI 0.55-0.89) and 0.87 (0.74-1.0) respectively. Cotrimoxazole may prevent the development of TB among HIV-positive persons, especially among those with no previous ART.

Type: Article
Title: Co-Trimoxazole Prophylaxis Is Associated with Reduced Risk of Incident Tuberculosis in Participants in the Swiss HIV Cohort Study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1128/AAC.01868-13
Publisher version: http://dx.doi.org/10.1128/AAC.01868-13
Language: English
Additional information: © 2014 American Society for Microbiology PubMed ID: 24514096
Keywords: Cotrimoxazole prophylaxis, HIV-infection, tuberculosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1428853
Downloads since deposit
130Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item