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Towards personalised management of atherosclerosis via computational models in vascular clinics: technology based on patient-specific simulation approach

Diaz, VA; Di Tomaso, G; Agu, O; Pichardo, C; (2014) Towards personalised management of atherosclerosis via computational models in vascular clinics: technology based on patient-specific simulation approach. Healthcare Technology Letters , 1 (1) 13 - 18. 10.1049/htl.2013.0040. Green open access

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Abstract

The development of a new technology based on patient-specific modelling for personalised healthcare in the case of atherosclerosis is presented. Atherosclerosis is the main cause of death in the world and it has become a burden on clinical services as it manifests itself in many diverse forms, such as coronary artery disease, cerebrovascular disease/stroke and peripheral arterial disease. It is also a multifactorial, chronic and systemic process that lasts for a lifetime, putting enormous financial and clinical pressure on national health systems. In this Letter, the postulate is that the development of new technologies for healthcare using computer simulations can, in the future, be developed as in-silico management and support systems. These new technologies will be based on predictive models (including the integration of observations, theories and predictions across a range of temporal and spatial scales, scientific disciplines, key risk factors and anatomical sub-systems) combined with digital patient data and visualisation tools. Although the problem is extremely complex, a simulation workflow and an exemplar application of this type of technology for clinical use is presented, which is currently being developed by a multidisciplinary team following the requirements and constraints of the Vascular Service Unit at the University College Hospital, London.

Type: Article
Title: Towards personalised management of atherosclerosis via computational models in vascular clinics: technology based on patient-specific simulation approach
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1049/htl.2013.0040
Publisher version: http://dx.doi.org/10.1049/htl.2013.0040
Additional information: This is an open access article published by the IET under the Creative Commons Attribution License (http://creativecommons. org/licenses/by/3.0/)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1428421
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