Wasan, H;
Meade, AM;
Adams, R;
Wilson, R;
Pugh, C;
Fisher, D;
Sydes, B;
... on behalf of the COIN-B investigators; + view all
(2014)
Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced colorectal cancer (COIN-B): a randomised phase 2 trial.
Lancet Oncology
, 15
(6)
pp. 631-639.
10.1016/S1470-2045(14)70106-8.
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Abstract
Advanced colorectal cancer is treated with a combination of cytotoxic drugs and targeted treatments. However, how best to minimise the time spent taking cytotoxic drugs and whether molecular selection can refine this further is unknown. The primary aim of this study was to establish how cetuximab might be safely and effectively added to intermittent chemotherapy.
| Type: | Article |
|---|---|
| Title: | Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced colorectal cancer (COIN-B): a randomised phase 2 trial |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/S1470-2045(14)70106-8 |
| Publisher version: | http://dx.doi.org/10.1016/S1470-2045(14)70106-8 |
| Language: | English |
| Additional information: | © Wasan et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1427773 |
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