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Neuronal adaptation involves rapid expansion of the action potential initiation site

Scott, RS; Henneberger, C; Padmashri, R; Anders, S; Jensen, TP; Rusakov, D; (2014) Neuronal adaptation involves rapid expansion of the action potential initiation site. Nature Communications , 5 , Article 3817. 10.1038/ncomms4817. Green open access

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Abstract

Action potential (AP) generation is the key to information processing in the brain. Although APs are normally initiated in the axonal initial segment, developmental adaptation or prolonged network activity may alter the initiation site geometry thus affecting cell excitability. Here we find that hippocampal dentate granule cells adapt their spiking threshold to the kinetics of the ongoing dendrosomatic excitatory input by expanding the AP initiation area away from the soma while also decelerating local axonal spikes. Dual-patch soma-axon recordings combined with axonal Na+ and Ca2+ imaging and biophysical modeling show that the underlying mechanism involves distance-dependent inactivation of axonal Na+ channels due to somatic depolarization propagating into the axon. Thus the ensuing changes in the AP initiation zone and local AP propagation could provide activity-dependent control of cell excitability and spiking on a relatively rapid time scale.

Type: Article
Title: Neuronal adaptation involves rapid expansion of the action potential initiation site
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/ncomms4817
Publisher version: http://dx.doi.org/10.1038/ncomms4817
Language: English
Additional information: © 2014 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/1427627
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