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Investigation of cerebral autoregulation in the newborn piglet during anaesthesia and surgery

Bale, G; Oliver-Taylor, A; Fierens, I; Broad, K; Hassell, J; Kawano, G; Rostami, J; ... Tachtsidis, I; + view all (2014) Investigation of cerebral autoregulation in the newborn piglet during anaesthesia and surgery. Advances in Experimental Medicine and Biology , 812 165 - 171. 10.1007/978-1-4939-0620-8_22. Green open access

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Abstract

The relationship between cerebral autoregulation (CA) and the neurotoxic effects of anaesthesia with and without surgery is investigated. Newborn piglets were randomly assigned to receive either 6 h of anaesthesia (isoflurane) or the same with an additional hour of minor surgery. The effect of the spontaneous changes in mean arterial blood pressure (MABP) on the cerebral haemodynamics (oxy- and deoxy-haemoglobin, HbO2 and Hb) was measured using transverse broadband near-infrared spectroscopy (NIRS). A marker for impaired CA, concordance between MABP and intravascular oxygenation (HbD = HbO2 - Hb) in the ultra-low frequency domain (0.0018-0.0083 Hz), was assessed using coherence analysis. Presence of CA impairment was not significant but found to increase with surgical exacerbation. The impairment did not correlate with histological outcome (presence of cell death, apoptosis and microglial activation in the brain).

Type: Article
Title: Investigation of cerebral autoregulation in the newborn piglet during anaesthesia and surgery
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4939-0620-8_22
Publisher version: http://dx.doi.org/10.1007/978-1-4939-0620-8_22
Language: English
Additional information: © Springer Science+Business Media, LLC 2014. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Keywords: Anesthesia, Animals, Animals, Newborn, Brain, Spectroscopy, Near-Infrared, Surgical Procedures, Operative, Swine
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Maternal and Fetal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Neonatology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1427480
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