Dearnaley, DP;
Jovic, G;
Syndikus, I;
Khoo, V;
Cowan, RA;
Graham, JD;
Aird, EG;
... Sydes, MR; + view all
(2014)
Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial.
The Lancet Oncology
, 15
(4)
464 - 473.
10.1016/S1470-2045(14)70040-3.
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Abstract
The aim of this trial was to compare dose-escalated conformal radiotherapy with control-dose conformal radiotherapy in patients with localised prostate cancer. Preliminary findings reported after 5 years of follow-up showed that escalated-dose conformal radiotherapy improved biochemical progression-free survival. Based on the sample size calculation, we planned to analyse overall survival when 190 deaths occurred; this target has now been reached, after a median 10 years of follow-up.
| Type: | Article |
|---|---|
| Title: | Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/S1470-2045(14)70040-3 |
| Publisher version: | http://dx.doi.org/10.1016/S1470-2045(14)70040-3 |
| Language: | English |
| Additional information: | Copyright 2014 © Dearnaley et al. Open Access article distributed under the terms of CC BY. |
| Keywords: | Aged, Aged, 80 and over, Androgen Antagonists, Chemotherapy, Adjuvant, Disease Progression, Disease-Free Survival, Dose Fractionation, Humans, Intention to Treat Analysis, Kallikreins, Kaplan-Meier Estimate, Male, Middle Aged, Neoadjuvant Therapy, Neoplasm Staging, Proportional Hazards Models, Prostate-Specific Antigen, Prostatic Neoplasms, Radiotherapy, Conformal, Risk Factors, Time Factors, Treatment Outcome |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1427382 |
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