Pasparakis, G;
Manouras, T;
Vamvakaki, M;
Argitis, P;
(2014)
Harnessing photochemical internalization with dual degradable nanoparticles for combinatorial photo-chemotherapy.
Nat Commun
, 5
, Article 3623. 10.1038/ncomms4623.
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Abstract
Light-controlled drug delivery systems constitute an appealing means to direct and confine drug release spatiotemporally at the site of interest with high specificity. However, the utilization of light-activatable systems is hampered by the lack of suitable drug carriers that respond sharply to visible light stimuli at clinically relevant wavelengths. Here, a new class of self-assembling, photo- and pH-degradable polymers of the polyacetal family is reported, which is combined with photochemical internalization to control the intracellular trafficking and release of anticancer compounds. The polymers are synthesized by simple and scalable chemistries and exhibit remarkably low photolysis rates at tunable wavelengths over a large range of the spectrum up to the visible and near infrared regime. The combinational pH and light mediated degradation facilitates increased therapeutic potency and specificity against model cancer cell lines in vitro. Increased cell death is achieved by the synergistic activity of nanoparticle-loaded anticancer compounds and reactive oxygen species accumulation in the cytosol by simultaneous activation of porphyrin molecules and particle photolysis.
Type: | Article |
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Title: | Harnessing photochemical internalization with dual degradable nanoparticles for combinatorial photo-chemotherapy. |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1038/ncomms4623 |
Publisher version: | http://dx.doi.org/10.1038/ncomms4623 |
Language: | English |
Additional information: | © 2014 Macmillan Publishers Limited. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
Keywords: | Biological sciences; Cancer; Nanotechnology; |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/1427292 |
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