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Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model.

Ezzati, M; Broad, K; Kawano, G; Faulkner, S; Hassell, J; Fleiss, B; Gressens, P; ... Robertson, NJ; + view all (2014) Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model. Acta Anaesthesiol Scand , 58 (6) pp. 733-742. 10.1111/aas.12318. Green open access

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Abstract

The highly selective α2 -adrenoreceptor agonist, dexmedetomidine, exerts neuroprotective, analgesic, anti-inflammatory and sympatholytic properties that may be beneficial for perinatal asphyxia. The optimal safe dose for pre-clinical newborn neuroprotection studies is unknown.

Type: Article
Title: Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/aas.12318
Publisher version: http://dx.doi.org/10.1111/aas.12318
Additional information: © 2014 The Authors. The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
URI: https://discovery.ucl.ac.uk/id/eprint/1427291
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