Ezzati, M;
Broad, K;
Kawano, G;
Faulkner, S;
Hassell, J;
Fleiss, B;
Gressens, P;
... Robertson, NJ; + view all
(2014)
Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model.
Acta Anaesthesiol Scand
, 58
(6)
pp. 733-742.
10.1111/aas.12318.
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Abstract
The highly selective α2 -adrenoreceptor agonist, dexmedetomidine, exerts neuroprotective, analgesic, anti-inflammatory and sympatholytic properties that may be beneficial for perinatal asphyxia. The optimal safe dose for pre-clinical newborn neuroprotection studies is unknown.
| Type: | Article |
|---|---|
| Title: | Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/aas.12318 |
| Publisher version: | http://dx.doi.org/10.1111/aas.12318 |
| Additional information: | © 2014 The Authors. The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1427291 |
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