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A hybrid oscillatory interference/continuous attractor network model of grid cell firing.

Bush, D; Burgess, N; (2014) A hybrid oscillatory interference/continuous attractor network model of grid cell firing. J Neurosci , 34 (14) 5065 - 5079. 10.1523/JNEUROSCI.4017-13.2014. Green open access

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Abstract

Grid cells in the rodent medial entorhinal cortex exhibit remarkably regular spatial firing patterns that tessellate all environments visited by the animal. Two theoretical mechanisms that could generate this spatially periodic activity pattern have been proposed: oscillatory interference and continuous attractor dynamics. Although a variety of evidence has been cited in support of each, some aspects of the two mechanisms are complementary, suggesting that a combined model may best account for experimental data. The oscillatory interference model proposes that the grid pattern is formed from linear interference patterns or "periodic bands" in which velocity-controlled oscillators integrate self-motion to code displacement along preferred directions. However, it also allows the use of symmetric recurrent connectivity between grid cells to provide relative stability and continuous attractor dynamics. Here, we present simulations of this type of hybrid model, demonstrate that it generates intracellular membrane potential profiles that closely match those observed in vivo, addresses several criticisms aimed at pure oscillatory interference and continuous attractor models, and provides testable predictions for future empirical studies.

Type: Article
Title: A hybrid oscillatory interference/continuous attractor network model of grid cell firing.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.4017-13.2014
Publisher version: http://dx.doi.org/10.1523/JNEUROSCI.4017-13.2014
Language: English
Additional information: Copyright © 2014 Bush and Burgess. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/1426300
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