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Childhood abuse is associated with methylation of multiple loci in adult DNA

Suderman, M; Borghol, N; Pappas, JJ; Pinto Pereira, SM; Pembrey, M; Hertzman, C; Power, C; (2014) Childhood abuse is associated with methylation of multiple loci in adult DNA. BMC Med Genomics , 7 (1) , Article 14. 10.1186/1755-8794-7-13. Green open access

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Abstract

Childhood abuse is associated with increased adult disease risk, suggesting that processes acting over the long-term, such as epigenetic regulation of gene activity, may be involved. DNA methylation is a critical mechanism in epigenetic regulation. We aimed to establish whether childhood abuse was associated with adult DNA methylation profiles.

Type: Article
Title: Childhood abuse is associated with methylation of multiple loci in adult DNA
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1755-8794-7-13
Publisher version: http://dx.doi.org/10.1186/1755-8794-7-13
Language: English
Additional information: © 2014 Suderman et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1425568
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