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Systematic review of novel ablative methods in locally advanced pancreatic cancer

Keane, MG; Bramis, K; Pereira, SP; Fusai, GK; (2014) Systematic review of novel ablative methods in locally advanced pancreatic cancer. World Journal of Gastroenterology , 20 (9) 2267 - 2278. 10.3748/wjg.v20.i9.2267. Green open access

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Abstract

Unresectable locally advanced pancreatic cancer with or without metastatic disease is associated with a very poor prognosis. Current standard therapy is limited to chemotherapy or chemoradiotherapy. Few regimens have been shown to have a substantial survival advantage and novel treatment strategies are urgently needed. Thermal and laser based ablative techniques are widely used in many solid organ malignancies. Initial studies in the pancreas were associated with significant morbidity and mortality, which limited widespread adoption. Modifications to the various applications, in particular combining the techniques with high quality imaging such as computed tomography and intraoperative or endoscopic ultrasound has enabled real time treatment monitoring and significant improvements in safety. We conducted a systematic review of the literature up to October 2013. Initial studies suggest that ablative therapies may confer an additional survival benefit over best supportive care but randomised studies are required to validate these findings.

Type: Article
Title: Systematic review of novel ablative methods in locally advanced pancreatic cancer
Location: China
Open access status: An open access version is available from UCL Discovery
DOI: 10.3748/wjg.v20.i9.2267
Publisher version: http://dx.doi.org/10.3748/wjg.v20.i9.2267
Language: English
Additional information: Copyright © 2014 Baishideng Publishing Group Inc. All rights reserved. Articles published by this open-access journal are distributed under the terms of the Creative Commons Attribution-Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.
Keywords: Cryoablation, High frequency focused ultrasound, Irreversible electroporation, Microwave ablation, Pancreatic cancer, Photodynamic therapy, Radiofrequency ablation, Ablation Techniques, Carcinoma, Pancreatic Ductal, Catheter Ablation, Cryosurgery, Electroporation, High-Intensity Focused Ultrasound Ablation, Humans, Laser Therapy, Microwaves, Pancreatic Neoplasms, Precancerous Conditions, Treatment Outcome
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/1425255
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