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Neural correlates of intentional and stimulus-driven inhibition: a comparison.

Schel, MA; Kühn, S; Brass, M; Haggard, P; Ridderinkhof, KR; Crone, EA; (2014) Neural correlates of intentional and stimulus-driven inhibition: a comparison. Front Hum Neurosci , 8 , Article 27. 10.3389/fnhum.2014.00027. Green open access

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Abstract

People can inhibit an action because of an instruction by an external stimulus, or because of their own internal decision. The similarities and differences between these two forms of inhibition are not well understood. Therefore, in the present study the neural correlates of intentional and stimulus-driven inhibition were tested in the same subjects. Participants performed two inhibition tasks while lying in the scanner: the marble task in which they had to choose for themselves between intentionally acting on, or inhibiting a prepotent response to measure intentional inhibition, and the classical stop signal task in which an external signal triggered the inhibition process. Results showed that intentional inhibition decision processes rely on a neural network that has been documented extensively for stimulus-driven inhibition, including bilateral parietal and lateral prefrontal cortex and pre-supplementary motor area. We also found activation in dorsal frontomedian cortex and left inferior frontal gyrus during intentional inhibition that depended on the history of previous choices. Together, these results indicate that intentional inhibition and stimulus-driven inhibition engage a common inhibition network, but intentional inhibition is also characterized by additional context-dependent neural activation in medial prefrontal cortex.

Type: Article
Title: Neural correlates of intentional and stimulus-driven inhibition: a comparison.
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fnhum.2014.00027
Publisher version: http://dx.doi.org/10.3389/fnhum.2014.00027
Language: English
Additional information: © 2014 Schel, Kühn, Brass, Haggard, Ridderinkhof and Crone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. PMCID: PMC3913912
Keywords: action, cognitive control, fMRI, response inhibition, volition
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1425009
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