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Microarrays and single molecules: an exciting combination.

Howorka, S; Hesse, J; (2014) Microarrays and single molecules: an exciting combination. Soft Matter , 10 (7) 931 - 941. 10.1039/c3sm52561a. Green open access

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Abstract

Biomolecules positioned at interfaces have spawned many applications in bioanalysis, biophysics, and cell biology. This Highlight describes recent developments in the research areas of protein and DNA arrays, and single-molecule sensing. We cover the ultrasensitive scanning of conventional microarrays as well as the generation of arrays composed of individual molecules. The combination of these tools has improved the detection limits and the dynamic range of microarray analysis, helped develop powerful single-molecule sequencing approaches, and offered biophysical examination with high throughput and molecular detail. The topic of this Highlight integrates several disciplines and is written for interested chemists, biophysicists and nanotechnologists.

Type: Article
Title: Microarrays and single molecules: an exciting combination.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c3sm52561a
Publisher version: http://dx.doi.org/http://discovery.ucl.ac.uk/14239...
Language: English
Additional information: © The Royal Society of Chemistry 2014. This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1423955
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