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Randomized trial of nicotine replacement therapy (NRT), bupropion and NRT plus bupropion for smoking cessation: Effectiveness in clinical practice

Stapleton, J; Abdi, Z; Strang, J; Sutherland, G; West, R; Vangeli, E; Hajek, P; ... Ali, R; + view all (2013) Randomized trial of nicotine replacement therapy (NRT), bupropion and NRT plus bupropion for smoking cessation: Effectiveness in clinical practice. Addiction , 108 (12) 2193 - 2201. 10.1111/add.12304. Green open access

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Abstract

Background and aims: Bupropion was introduced for smoking cessation following a pivotal trial showing that it gave improved efficacy over the nicotine patch and also suggesting combination treatment was beneficial. We tested in clinical practice for an effectiveness difference between bupropion and nicotine replacement therapy (NRT), whether the combination improves effectiveness and whether either treatment might be more beneficial for certain subgroups of smokers. Design: Open-label randomized controlled trial with 6-month follow-up. Setting: Four UK National Health Service (NHS) smoking cessation clinics. Participants: Smokers (n=1071) received seven weekly behavioural support sessions and were randomized to an NRT product of their choice (n=418), bupropion (n=409) or NRT plus bupropion (n=244). Measures: The primary outcome was self-reported cessation over 6 months, with biochemical verification at 1 and 6 months. Also measured were baseline demographics, health history, smoking characteristics and unwanted events during treatment. Findings: Abstinence rates for bupropion (27.9%) and NRT (24.2%) were not significantly different (odds ratio=1.21, 95% confidence interval =0.883-1.67), and the combination rate (24.2%) was similar to that for either treatment alone. There was some evidence that the relative effectiveness of bupropion and NRT differed according to depression (χ=2.86, P=0.091), with bupropion appearing more beneficial than NRT in those with a history of depression (29.8 versus 18.5%). Several unwanted symptoms were more common with bupropion. Conclusion: There is no difference in smoking cessation effectiveness among bupropion, nicotine replacement therapy and their combination when used with behavioural support in clinical practice. There is some evidence that bupropion is more beneficial than nicotine replacement therapy for smokers with a history of depression. © 2013 Society for the Study of Addiction.

Type: Article
Title: Randomized trial of nicotine replacement therapy (NRT), bupropion and NRT plus bupropion for smoking cessation: Effectiveness in clinical practice
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/add.12304
Publisher version: http://dx.doi.org/10.1111/add.12304
Additional information: © 2013 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Bupropion; combination treatment; depression; NHS; NRT; randomized trial; smoking cessation; varenicline;
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
URI: https://discovery.ucl.ac.uk/id/eprint/1423815
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