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Neuropilin regulation of angiogenesis, arteriogenesis and vascular permeability.

Plein, A; Fantin, A; Ruhrberg, C; (2014) Neuropilin regulation of angiogenesis, arteriogenesis and vascular permeability. Microcirculation , 21 (4) pp. 315-323. 10.1111/micc.12124. Green open access

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Abstract

The formation of the cardiovasculature, consisting of both the heart and blood vessels, is a critical step in embryonic development and relies on three processes termed vasculogenesis, angiogenesis and vascular remodelling. The transmembrane protein neuropilin 1 (NRP1) is an essential modulator of embryonic angiogenesis with additional roles in vessel remodelling and arteriogenesis. NRP1 also enhances arteriogenesis in adults to alleviate pathological tissue ischemia. However, in certain circumstances, vascular NRP1 signalling can be detrimental, as it may promote cancer by enhancing tumour angiogenesis or contribute to tissue oedema by increasing vascular permeability. Understanding the mechanisms of NRP1 signalling is therefore of profound importance for the design of therapies aiming to control vascular functions. Previous work has shown that vascular NRP1 can variably serve as a receptor for the secreted glycoproteins VEGF-A or SEMA3A, but it also has a poorly understood role as an adhesion receptor. Here, we review current knowledge of NRP1 function during blood vessel growth and homeostasis, with special emphasis on the vascular roles of its multiple ligands and signalling partners. This article is protected by copyright. All rights reserved.

Type: Article
Title: Neuropilin regulation of angiogenesis, arteriogenesis and vascular permeability.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/micc.12124
Publisher version: http://dx.doi.org/10.1111/micc.12124
Additional information: © 2014 The Authors. Microcirculation Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Angiogenesis, NRP1, Neuropilin, SEMA3A, VEGF, VEGF-A, VEGFR2, angiogenesis, arteriogenesis, endothelial cells, vascular permeability
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1423436
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