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Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability.

Fiore, VG; Mannella, F; Mirolli, M; Latagliata, EC; Valzania, A; Cabib, S; Dolan, RJ; ... Baldassarre, G; + view all (2015) Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability. Brain Struct Funct , 220 (3) 1339 - 1353. 10.1007/s00429-014-0727-7. Green open access

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Abstract

Appraisal of a stressful situation and the possibility to control or avoid it is thought to involve frontal-cortical mechanisms. The precise mechanism underlying this appraisal and its translation into effective stress coping (the regulation of physiological and behavioural responses) are poorly understood. Here, we propose a computational model which involves tuning motivational arousal to the appraised stressing condition. The model provides a causal explanation of the shift from active to passive coping strategies, i.e. from a condition characterised by high motivational arousal, required to deal with a situation appraised as stressful, to a condition characterised by emotional and motivational withdrawal, required when the stressful situation is appraised as uncontrollable/unavoidable. The model is motivated by results acquired via microdialysis recordings in rats and highlights the presence of two competing circuits dominated by different areas of the ventromedial prefrontal cortex: these are shown having opposite effects on several subcortical areas, affecting dopamine outflow in the striatum, and therefore controlling motivation. We start by reviewing published data supporting structure and functioning of the neural model and present the computational model itself with its essential neural mechanisms. Finally, we show the results of a new experiment, involving the condition of repeated inescapable stress, which validate most of the model's predictions.

Type: Article
Title: Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability.
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00429-014-0727-7
Publisher version: http://dx.doi.org/10.1007/s00429-014-0727-7
Language: English
Additional information: © The Author(s) 2014. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1423365
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