Richter, N;
Simon, RC;
Kroutil, W;
Ward, JM;
Hailes, HC;
(2014)
Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase.
Chem Commun (Camb)
, 50
pp. 6098-6100.
10.1039/c3cc49080g.
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Abstract
An efficient and sustainable biocatalytic route for the synthesis of important 17-α-amino steroids has been developed using an ω-transaminase variant from Arthrobacter sp. Optimisation of the reaction conditions facilitated the synthesis of these valuable synthons on a preparative scale, affording excellent isolated yields and stereocontrol.
| Type: | Article |
|---|---|
| Title: | Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c3cc49080g |
| Publisher version: | http://dx.doi.org/10.1039/c3cc49080g |
| Additional information: | © The Royal Society of Chemistry 2014. Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1423331 |
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