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Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase.

Richter, N; Simon, RC; Kroutil, W; Ward, JM; Hailes, HC; (2014) Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase. Chem Commun (Camb) , 50 pp. 6098-6100. 10.1039/c3cc49080g. Green open access

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Abstract

An efficient and sustainable biocatalytic route for the synthesis of important 17-α-amino steroids has been developed using an ω-transaminase variant from Arthrobacter sp. Optimisation of the reaction conditions facilitated the synthesis of these valuable synthons on a preparative scale, affording excellent isolated yields and stereocontrol.

Type: Article
Title: Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c3cc49080g
Publisher version: http://dx.doi.org/10.1039/c3cc49080g
Additional information: © The Royal Society of Chemistry 2014. Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1423331
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