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Stratified medicine for mental disorders

Schumann, G; Binder, EB; Holte, A; de Kloet, ER; Oedegaard, KJ; Robbins, TW; Walker-Tilley, TR; ... Wittchen, HU; + view all (2014) Stratified medicine for mental disorders. European Neuropsychopharmacology , 24 (1) pp. 5-50. 10.1016/j.euroneuro.2013.09.010. Green open access

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Abstract

There is recognition that biomedical research into the causes of mental disorders and their treatment needs to adopt new approaches to research. Novel biomedical techniques have advanced our understanding of how the brain develops and is shaped by behaviour and environment. This has led to the advent of stratified medicine, which translates advances in basic research by targeting aetiological mechanisms underlying mental disorder. The resulting increase in diagnostic precision and targeted treatments may provide a window of opportunity to address the large public health burden, and individual suffering associated with mental disorders. While mental health and mental disorders have significant representation in the “health, demographic change and wellbeing” challenge identified in Horizon 2020, the framework programme for research and innovation of the European Commission (2014–2020), and in national funding agencies, clear advice on a potential strategy for mental health research investment is needed. The development of such a strategy is supported by the EC-funded “Roadmap for Mental Health Research” (ROAMER) which will provide recommendations for a European mental health research strategy integrating the areas of biomedicine, psychology, public health well being, research integration and structuring, and stakeholder participation. Leading experts on biomedical research on mental disorders have provided an assessment of the state of the art in core psychopathological domains, including arousal and stress regulation, affect, cognition social processes, comorbidity and pharmacotherapy. They have identified major advances and promising methods and pointed out gaps to be addressed in order to achieve the promise of a stratified medicine for mental disorders.

Type: Article
Title: Stratified medicine for mental disorders
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.euroneuro.2013.09.010
Publisher version: http://dx.doi.org/10.1016/j.euroneuro.2013.09.010
Language: English
Additional information: Copyright © 2017 Elsevier B.V. or its licensors or contributors. This is an open-access article distributed under the terms of the (Creative Commons Attribution Non Commercial License: https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
Keywords: Mental Disorder, Road Map, Stratified Medicine, Psychopathology, Neural Processes, Treatment, Major Depressive Disorder, Treatment-resistant Depression, Genome-wide Association, Ventral Tegmental Area, Psychiatric-disorders, Prefrontal Cortex, Anxiety Disorders, Bipolar Disorder, Working-memory, Environment Interactions
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/1423246
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