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Mitochondrial fusion and fission proteins: Novel therapeutic targets for combating cardiovascular disease.

Hall, A; Burke, N; Dongworth, R; Hausenloy, D; (2014) Mitochondrial fusion and fission proteins: Novel therapeutic targets for combating cardiovascular disease. Br J Pharmacol , 171 (8) pp. 1890-1906. 10.1111/bph.12516. Green open access

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Abstract

Mitochondria are no longer considered to be solely the static power-houses of the cell. Whilst they are undoubtedly essential to sustaining life and meeting the energy requirements of the cell through oxidative phosphorylation, they are now regarded as highly dynamic organelles with multiple functions, playing key roles in cell survival and death. In this review, we discuss the emerging role of mitochondrial fusion and fission proteins, as novel therapeutic targets for treating a wide range of cardiovascular diseases.

Type: Article
Title: Mitochondrial fusion and fission proteins: Novel therapeutic targets for combating cardiovascular disease.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bph.12516
Publisher version: http://dx.doi.org/10.1111/bph.12516
Additional information: © 2013 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: Drp1, MFN1, MFN2, Mitochondrial dynamics, Mitochondrial fission, Mitochondrial fusion, Mitochondrial morphology, OPA1
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/1423227
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