Sandanayake, NS; Camuzeaux, S; Sinclair, J; Blyuss, O; Andreola, F; Chapman, MH; Webster, GJ; ... Pereira, SP; + view all Sandanayake, NS; Camuzeaux, S; Sinclair, J; Blyuss, O; Andreola, F; Chapman, MH; Webster, GJ; Smith, RC; Timms, JF; Pereira, SP; - view fewer (2014) Identification of potential serum peptide biomarkers of biliary tract cancer using MALDI MS profiling. BMC Clinical Pathology , 14 (1) , Article 7. 10.1186/1472-6890-14-7.

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Abstract

The aim of this discovery study was the identification of peptide serum biomarkers for detecting biliary tract cancer (BTC) using samples from healthy volunteers and benign cases of biliary disease as control groups. This work was based on the hypothesis that cancer-specific exopeptidase activities in serum can generate cancer-predictive peptide fragments from circulating proteins during coagulation.

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