Smittenaar, P;
Fitzgerald, TH;
Romei, V;
Wright, ND;
Dolan, RJ;
(2013)
Disruption of Dorsolateral Prefrontal Cortex Decreases Model-Based in Favor of Model-free Control in Humans.
Neuron
, 80
(4)
pp. 914-919.
10.1016/j.neuron.2013.08.009.
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Abstract
Human choice behavior often reflects a competition between inflexible computationally efficient control on the one hand and a slower more flexible system of control on the other. This distinction is well captured by model-free and model-based reinforcement learning algorithms. Here, studying human subjects, we show it is possible to shift the balance of control between these systems by disruption of right dorsolateral prefrontal cortex, such that participants manifest a dominance of the less optimal model-free control. In contrast, disruption of left dorsolateral prefrontal cortex impaired model-based performance only in those participants with low working memory capacity.
| Type: | Article |
|---|---|
| Title: | Disruption of Dorsolateral Prefrontal Cortex Decreases Model-Based in Favor of Model-free Control in Humans. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuron.2013.08.009 |
| Publisher version: | http://dx.doi.org/10.1016/j.neuron.2013.08.009 |
| Additional information: | © 2013 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1422038 |
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