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Joan Mott Prize Lecture 2013 - Memory consolidation in humans: New evidence and opportunities.

Maguire, EA; (2014) Joan Mott Prize Lecture 2013 - Memory consolidation in humans: New evidence and opportunities. Exp Physiol , 99 (3) pp. 471-486. 10.1113/expphysiol.2013.072157. Green open access

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Abstract

We are endlessly fascinated by memory; we desire to improve it and fear its loss. While it has long been recognised that brain regions such as the hippocampus are vital for supporting memories of our past experiences - autobiographical memories - we still lack fundamental knowledge about the mechanisms involved. This is because the study of specific neural signatures of autobiographical memories in vivo in humans presents a significant challenge. However, recent developments in high-resolution structural and functional magnetic resonance imaging (MRI) coupled with advanced analysis methods now permit access to the neural substrates of memory representations that has hitherto been precluded in humans. Here I describe how the application of 'decoding' techniques to brain imaging data is beginning to disclose how individual autobiographical memory representations evolve over time, deepening our understanding of systems-level consolidation, prompting in particular new questions about the roles of the hippocampus and ventromedial prefrontal cortex, and offering new opportunities to interrogate the elusive memory trace that has for so long confounded neuroscientists.

Type: Article
Title: Joan Mott Prize Lecture 2013 - Memory consolidation in humans: New evidence and opportunities.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1113/expphysiol.2013.072157
Publisher version: http://dx.doi.org/10.1113/expphysiol.2013.072157
Additional information: © 2013 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: autobiographical memory, consolidation, hippocampus
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1421329
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