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An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis.

Sandeman, SR; Howell, CA; Phillips, GJ; Zheng, Y; Standen, G; Pletzenauer, R; Davenport, A; ... Mikhalovsky, SV; + view all (2014) An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis. J Mater Sci Mater Med , 25 (6) 1589 - 1597. 10.1007/s10856-014-5173-9. Green open access

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Abstract

Adsorbents designed with porosity which allows the removal of protein bound and high molecular weight uraemic toxins may improve the effectiveness of haemodialysis treatment of chronic kidney disease (CKD). A nanoporous activated carbon monolith prototype designed for direct blood contact was first assessed for its capacity to remove albumin bound marker toxins indoxyl sulphate (IS), p-cresyl sulphate (p-CS) and high molecular weight cytokine interleukin-6 in spiked healthy donor studies. Haemodialysis patient blood samples were then used to measure the presence of these markers in pre- and post-dialysis blood and their removal by adsorbent recirculation of post-dialysis blood samples. Nanopores (20-100 nm) were necessary for marker uraemic toxin removal during in vitro studies. Limited removal of IS and p-CS occurred during haemodialysis, whereas almost complete removal occurred following perfusion through the carbon monoliths suggesting a key role for such adsorbent therapies in CKD patient care.

Type: Article
Title: An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s10856-014-5173-9
Publisher version: http://dx.doi.org/10.1007/s10856-014-5173-9
Language: English
Additional information: © The Author(s) 2014. This article is published with open access at Springerlink.com
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1420891
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