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Gentamicin, genetic variation and deafness in preterm children.

Bitner-Glindzicz, M; Rahman, S; Chant, K; Marlow, N; (2014) Gentamicin, genetic variation and deafness in preterm children. BMC Pediatr , 14 (1) , Article 66. 10.1186/1471-2431-14-66. Green open access

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Abstract

Hearing loss in children born before 32 weeks of gestation is more prevalent than in full term infants. Aminoglycoside antibiotics are routinely used to treat bacterial infections in babies on neonatal intensive care units. However, this type of medication can have harmful effects on the auditory system. In order to avoid this blood levels should be maintained in the therapeutic range. However in individuals with a mitochondrial genetic variant (m.1555A > G), permanent hearing loss can occur even when drug levels are within normal limits. The aim of the study is to investigate the burden that the m.1555A > G mutation represents to deafness in very preterm infants.

Type: Article
Title: Gentamicin, genetic variation and deafness in preterm children.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2431-14-66
Publisher version: http://dx.doi.org/10.1186/1471-2431-14-66
Additional information: © 2014 Bitner-Glindzicz et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Gentamicin; Aminoglycosides; Deafness; Hearing loss; Mitochondrial; m.1555A > G; Preterm; Prematurity;
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1420702
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