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Human hippocampal processing of environmental novelty during spatial navigation.

Kaplan, R; Horner, AJ; Bandettini, PA; Doeller, CF; Burgess, N; (2014) Human hippocampal processing of environmental novelty during spatial navigation. Hippocampus , 24 (7) pp. 740-750. 10.1002/hipo.22264. Green open access

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Abstract

The detection and processing of novel information encountered as we explore our environment is crucial for learning and adaptive behavior. The human hippocampus has been strongly implicated in laboratory tests of novelty detection and episodic memory, but has been less well studied during more ethological tasks such as spatial navigation, typically used in animals. We examined fMRI BOLD activity as a function of environmental and object novelty as humans performed an object-location virtual navigation task. We found greater BOLD response to novel relative to familiar environments in the hippocampus and adjacent parahippocampal gyrus. Object novelty was associated with increased activity in the posterior parahippocampal/fusiform gyrus and anterior hippocampus extending into the amygdala and superior temporal sulcus. Importantly, whilst mid-posterior hippocampus was more sensitive to environmental novelty than object novelty, the anterior hippocampus responded similarly to both forms of novelty. By investigating how participants learn and utilize different forms of information during spatial navigation, we found that MTL activity reflects both the novelty of the environment and of the object located within it. Crucially, this novelty processing is likely supported by distinct, but partially overlapping, sets of regions within the MTL. © 2014 Wiley Periodicals, Inc.

Type: Article
Title: Human hippocampal processing of environmental novelty during spatial navigation.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/hipo.22264
Publisher version: http://dx.doi.org/10.1002/hipo.22264
Additional information: © 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: MTL, amygdala, content, context, fMRI
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1419882
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