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Medial Prefrontal Theta Phase Coupling during Spatial Memory Retrieval.

Kaplan, R; Bush, D; Bonnefond, M; Bandettini, PA; Barnes, GR; Doeller, CF; Burgess, N; (2014) Medial Prefrontal Theta Phase Coupling during Spatial Memory Retrieval. Hippocampus , 24 (6) pp. 656-665. 10.1002/hipo.22255. Green open access

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Abstract

Memory retrieval is believed to involve a disparate network of areas, including medial prefrontal and medial temporal cortices, but the mechanisms underlying their coordination remain elusive. One suggestion is that oscillatory coherence mediates inter-regional communication, implicating theta phase and theta-gamma phase-amplitude coupling in mnemonic function across species. To examine this hypothesis, we used non-invasive whole-head magnetoencephalography (MEG) as participants retrieved the location of objects encountered within a virtual environment. We demonstrate that, when participants are cued with the image of an object whose location they must subsequently navigate to, there is a significant increase in 4-8Hz theta power in medial prefrontal cortex (mPFC), and the phase of this oscillation is coupled both with ongoing theta phase in the medial temporal lobe (MTL) and perceptually induced 65-85Hz gamma amplitude in medial parietal cortex. These results suggest that theta phase coupling between mPFC and MTL and theta-gamma phase-amplitude coupling between mPFC and neocortical regions may play a role in human spatial memory retrieval. © 2014 Wiley Periodicals, Inc.

Type: Article
Title: Medial Prefrontal Theta Phase Coupling during Spatial Memory Retrieval.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/hipo.22255
Publisher version: http://dx.doi.org/10.1002/hipo.22255
Additional information: © 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: MEG, MTL, hippocampus, mPFC, oscillations
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1419537
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