UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Functional specialization within rostral prefrontal cortex (area 10): a meta-analysis

Gilbert, S.J.; Spengler, S.; Simons, J.S.; Steele, J.D.; Lawrie, S.M.; Frith, C.D.; Burgess, P.W.; (2006) Functional specialization within rostral prefrontal cortex (area 10): a meta-analysis. Journal of Cognitive Neuroscience , 18 (6) pp. 932-948. 10.1162/jocn.2006.18.6.932. Green open access

[img]
Preview
PDF
14190.pdf

Download (539kB)

Abstract

One of the least well understood regions of the human brain is rostral prefrontal cortex, approximating Brodmann's area 10. Here, we investigate the possibility that there are functional subdivisions within this region by conducting a meta-analysis of 104 functional neuroimaging studies (using positron emission tomography/functional magnetic resonance imaging). Studies involving working memory and episodic memory retrieval were disproportionately associated with lateral activations, whereas studies involving mentalizing (i.e., attending to one's own emotions and mental states or those of other agents) were disproportionately associated with medial activations. Functional variation was also observed along a rostral-caudal axis, with studies involving mentalizing yielding relatively caudal activations and studies involving multiple-task coordination yielding relatively rostral activations. A classification algorithm was trained to predict the task, given the coordinates of each activation peak. Performance was well above chance levels (74% for the three most common tasks; 45% across all eight tasks investigated) and generalized to data not included in the training set. These results point to considerable functional segregation within rostral prefrontal cortex.

Type: Article
Title: Functional specialization within rostral prefrontal cortex (area 10): a meta-analysis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1162/jocn.2006.18.6.932
Publisher version: http://dx.doi.org/10.1162/jocn.2006.18.6.932
Language: English
Additional information: Copyright 2006 Massachusetts Institute of Technology
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/14190
Downloads since deposit
1,022Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item