Dhankher, P;
Sheppard, TD;
(2014)
A Convenient Synthesis of Tri- and Tetramethylbenzaldehydes from Readily Available Phenols.
Synlett
, 25
(3)
381 - 384.
10.1055/s-0033-1340302.
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Abstract
This letter describes a convenient synthesis of the six isomeric tri- and tetramethylbenzaldehydes, which are not readily available from major chemical suppliers. Formylation of readily available phenols via electrophilic aromatic substitution provides compounds containing the correct aromatic substitution pattern. Suzuki cross-coupling of the corresponding trifluoromethanesulfonates with methylboronic acid then provides the benzaldehydes as single isomers.
| Type: | Article |
|---|---|
| Title: | A Convenient Synthesis of Tri- and Tetramethylbenzaldehydes from Readily Available Phenols |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1055/s-0033-1340302 |
| Publisher version: | http://dx.doi.org/10.1055/s-0033-1340302 |
| Language: | English |
| Additional information: | © Georg Thieme Verlag Stuttgart · New York |
| Keywords: | Aldehydes, Palladium, Suzuki, Aromatic compounds, Formylation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1418964 |
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